The Boston Globe ran a great article summarizing current views on the complex factors that play into depression. It's does a really affective job of summarizing how depression is affected by genetic, developmental and stress factors. Here's the key quote, describing how depression works (excerpt from the article):
"I would say that there is an interplay of genetic, developmental, and stress factors, and the contribution of each of these factors varies from individual to individual. Some individuals, for example, are depressed only if there is overwhelming stress. Others are vulnerable because of their genetic make up and become depressed with minor stressors."
Here's a link to the complete article:
An evolving view of depression - The Boston Globe
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